Customer
Case Study
Medical Devices · Cancer Diagnostics

Biological Dynamics entrusts Rogue Valley Microdevices with fabricating the sensors behind its lab-on-a-chip cancer diagnostics

How deep surface-science expertise, careful control of fabrication tolerances, and a shared Six Sigma discipline help enable a sample-to-answer platform that isolates exosomes, DNA, and RNA directly from blood.

Biological Dynamics lab-on-a-chip device
Customer
Industry
Medical devices · cancer diagnostics
Challenge
A novel lab-on-a-chip biosensor demanded unique, complex fabrication processes
Solution
Precision-manufactured sensing devices that isolate macromolecules from whole blood
Value of RVM’s role
Surface-science depth, tight tolerance control, and Six Sigma rigor
Isolated directly from blood
Exosomes
Cell-free DNA
RNA
Proteins
Captured from whole blood, serum, or plasma—with no sample pre-processing.
01

Enabling accessible cancer diagnostics

The proliferation of new cancer drugs and changes in the delivery of cancer care over the past decade have brought significant complexity to treatment pathways—while diagnostics capable of meeting these new paradigms have seen limited progress.

Biological Dynamics is an innovative diagnostic company committed to improving global cancer outcomes by empowering healthcare communities with accessible cancer diagnostics. The company is developing a portfolio of novel oncology products designed to enable early detection and individualized monitoring of cancer across multiple care settings.

At the heart of its approach is a proprietary “lab-on-a-chip” platform that directly isolates cell-free nanoparticles and macromolecules from whole blood, serum, or plasma—without the need to pre-process samples.

Rogue Valley Microdevices manufactures the sensing devices embedded in Biological Dynamics’ technology platform, enabling the isolation of exosomes, DNA, and RNA at the core of its diagnostic workflow.

“The ability to directly access critical biomarkers is extremely valuable and an exceptionally complex process to achieve, which makes finding the right device-manufacturing partner critical. … We were impressed by the Rogue Valley team’s dedication to customer service, technology expertise, and flexibility.”
Raj Krishnan, Ph.D.  ·  Founder & CEO, Biological Dynamics
Sample-to-Answer Workflow

A simple workflow, an advanced interface

The platform is designed to deliver a simple sample-to-answer workflow for the isolation and detection of macromolecular targets—cell-free DNA, exosomes, and proteins—from biological fluids, interacting with nanoparticles through an advanced electrical interface.

From sample to answer
Sample
Whole blood, serum, or plasma—no pre-processing
Lab-on-a-chip
Advanced electrical interface engages nanoparticles
Isolate
Exosomes, cell-free DNA, and RNA
Answer
Detection of macromolecular targets & proteins
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Why Rogue Valley Microdevices

Biological Dynamics’ innovative approach created an additional challenge—developing unique and complex manufacturing processes—and the company needed a partner it could trust with the science behind the device.

Surface-science expertise

A deep understanding of surface science—essential to a device that interacts with nanoparticles through an electrical interface.

Tolerance control

Experience engineering around the demanding fabrication tolerances inherent to a novel biosensor.

Six Sigma discipline

Adherence to Biological Dynamics’ Six Sigma approach for the continuous improvement of its devices.

“Biological Dynamics’ technology has the potential to dramatically advance the ways in which the healthcare industry assesses cancerous tumors. Providing a technology platform that is easy to use and accessible will help democratize the diagnostic process, removing the established barriers to gaining potentially life-saving or life-enhancing information. We are delighted to partner with Biological Dynamics in manufacturing the sensing device that is essential to their molecular diagnostic platform and look forward to supporting them as they further develop and commercialize their platform.”
Jessica Gomez  ·  Co-founder & CEO, Rogue Valley Microdevices
RVM cleanroom fabrication
Precision fabrication in the RVM cleanroom
Rogue Valley Microdevices
Your biomedical manufacturing partner

Fabricating the Future

Manufacturing advanced biomedical devices with the precision and rigor your science demands.

943 Automation Way, Suite F
Medford, OR 97504
541‑774‑1900
info@roguevalleymicrodevices.com
roguevalleymicrodevices.com
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